Amiodarone hydrochloride

Research use only, not for human use.

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Cell Proliferation Assay Cell Line:HELFs Concentration:1, 3 and 6?μg/mLIncubation Time:24?hours Result:Increased HELFs proliferation compared with the control group.Western Blot Analysis Cell Line:HELFs Concentration:1, 3 and 6?μg/mL Incubation Time:24?hoursResult:α-SMA and vimentin were increased signi?cantly in a dose-dependent manner.RT-PCRCell Line:HELFs Concentration:1, 3 and 6?μg/mL Incubation Time:24?hours Result:Induced an increase of α-SMA and vimentin mRNA expression.

Animal Model:Ten-week-old male C57BL/6 miceDosage:30, 90, and 180 mg/kg/day Administration:Treated orally; for 6 weeks Result:Mice treated with 90 and 180 mg/kg/day had decreased body and heart weights, although their heart weight-to-body weight ratios were not significantly different from sham. 6-week treatment induced a decrease in plasma triiodothyronine and an increase in reverse triiodothyronine. This effect reached significance for the 90 and 180 but not for the 30 mg/kg/day dose groups.

Amiodarone hydrochloride | NSC 85442 | NSC-85442 | NSC85442

Endocrinology/Hormones

Adrenergic Receptor

β-adrenergic receptor| Potassium Channel

Cardiovascular Disease

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19774-82-4

681.78

C25H29I2NO3·HCl

>98% (HPLC)

Ethanol: 11 mg/mL (16.13 mM); DMSO: 23 mg/mL (33.73 mM)

O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.[H]Cl

2-Butyl-3-benzofuryl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride

(-20℃)

With Ice Pack

≥ 2 years